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Compartment syndrome is associated with functional or total loss of a limb. It is readily diagnosible and treatable if attended to in a timely manner.

Link above gives a good overview of the symptoms of compartment syndrome.  Compartment syndrome occurs when there is increased pressure in the compartments of the arms, legs or abodmen.  The increase pressures affect blood flow to the tissues.  Lack of blood flow can cause tissue death within 4-8 hours.  Pain, pulselessness, paresthesia, poikliothermia, and pallor are the 5 ps of compartment syndrome.  This complication can be catastrophic if not diagnosed in a timely manner.  It can lead to amputation or permanent dysfunction in the affected areas.